Fueling Physiology: How Bioenergetics Drive Biological Function

Animals consume nutrients such as carbohydrates and fats to fuel their biological function.  Nutrient breakdown produces intermediate energy carriers that directly participate in reactions to do chemical work.  Drugs that modulate biological function also alter the chemical work reactions to produce bioenergetic signatures.  This 45-minute webinar discusses how a basic understanding of the fundamental principles governing these processes can help you understand the importance of incorporating bioenergetics in your research or drug discovery program.

Also discussed:

• How the bioenergetic state of a cell affects its behavior and response to stimulation
• The best way to rapidly measure cellular bioenergetics and metabolism
•  How bioenergetics can be used to understand cellular responses to RTK
  or GPCR signaling 

View On-Demand Webinar

January 19, 2008

Event ID# 1042906

References and Additional Links

Early Microphysiometer Techniques:

Wiley C, Beeson C.  Continuous measurement of glucose utilization in heart myoblasts.  Anal. Biochem. 2002  304(2):139-46.

Guppy M, Leedman P, Zu X, Russell V.  Biochem. J. 2002 364(Pt 1):309-15.  Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells.

Eklund SE, Taylor D, Kozlov E, Prokop A, Cliffel DE.  A microphysiometer for simultaneous measurement of changes in extracellular glucose, lactate, oxygen, and acidification rate.  Anal. Chem. 2004 76(3):519-27. 

Related Research in the Beeson Lab:

Sridharan V, Guichard J, Bailey RM, Kasiganesan H, Beeson C, Wright GL.  The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition.  Am. J. Physiol. Cell Physiol. 2007  292(2):C719-28.

Beeson Group Website
http://people.musc.edu/~beesonc/

 

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